3MHO

Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide

Summary for 3MHO

Entry DOI	10.2210/pdb3mho/pdb
Related	3M2N 3M3X 3M40 3M5E 3MHI 3MHL 3MHM
Descriptor	Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, sulfonamide, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29869.56
Authors	Grazulis, S.,Manakova, E.,Golovenko, D.,Sukackaite, R. (deposition date: 2010-04-08, release date: 2010-10-20, Last modification date: 2023-11-01)
Primary citation	Sudzius, J.,Baranauskiene, L.,Golovenko, D.,Matuliene, J.,Michailoviene, V.,Torresan, J.,Jachno, J.,Sukackaite, R.,Manakova, E.,Grazulis, S.,Tumkevicius, S.,Matulis, D. 4-[N-(Substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII Bioorg.Med.Chem., 18:7413-7421, 2010 Cited by PubMed: 20889345 DOI: 10.1016/j.bmc.2010.09.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation