3MH2

Mutagenesis of p38 MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-out state

Replaces:  2PTO

Summary for 3MH2

• Entry DOI: 10.2210/pdb3mh2/pdb
• Related: 3MGY 3MH0 3MH1 3MH3
• Descriptor: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside (3 entities in total)
• Functional Keywords: signaling protein, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41651.56

Authors

Namboodiri, H.V.,Karpusas, M.,Bukhtiyarova, M.,Springman, E.B. (deposition date: 2010-04-07, release date: 2010-04-21, Last modification date: 2023-09-06)

• Primary citation: Bukhtiyarova, M.,Karpusas, M.,Northrop, K.,Namboodiri, H.V.,Springman, E.B.; Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.; Biochemistry, 46:5687-5696, 2007; PubMed: 17441692; DOI: 10.1021/bi0622221

Experimental method

X-RAY DIFFRACTION (2.3 Å)