3MB7

Human CK2 catalytic domain in complex with a difurane derivative inhibitor (AMR)

Summary for 3MB7

Entry DOI	10.2210/pdb3mb7/pdb
Related	3MB6
Descriptor	Casein kinase II subunit alpha, naphtho[2,1-b:7,8-b']difuran-2,9-dicarboxylic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinases, difurane, inhibitor, ck2, atp-binding, kinase, nucleotide-binding, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	40138.58
Authors	Reiser, J.-B.,Prudent, R.,Cochet, C. (deposition date: 2010-03-25, release date: 2010-05-05, Last modification date: 2023-09-06)
Primary citation	Lopez-Ramos, M.,Prudent, R.,Moucadel, V.,Sautel, C.F.,Barette, C.,Lafanechere, L.,Mouawad, L.,Grierson, D.,Schmidt, F.,Florent, J.C.,Filippakopoulos, P.,Bullock, A.N.,Knapp, S.,Reiser, J.B.,Cochet, C. New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. Faseb J., 24:3171-3185, 2010 Cited by PubMed: 20400536 DOI: 10.1096/fj.09-143743 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation