3M67

Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide

Summary for 3M67

Entry DOI	10.2210/pdb3m67/pdb
Related	3m2n 3m3x 3m40 3m5e
Descriptor	Carbonic anhydrase 2, 2-chloro-5-[(6,7-dihydro-1H-[1,4]dioxino[2,3-f]benzimidazol-2-ylsulfanyl)acetyl]benzenesulfonamide, ZINC ION, ... (5 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	29950.63
Authors	Grazulis, S.,Manakova, E.,Golovenko, D. (deposition date: 2010-03-15, release date: 2010-11-03, Last modification date: 2023-11-01)
Primary citation	Capkauskaite, E.,Baranauskiene, L.,Golovenko, D.,Manakova, E.,Grazulis, S.,Tumkevicius, S.,Matulis, D. Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII Bioorg.Med.Chem., 18:7357-7364, 2010 Cited by PubMed: 20926301 DOI: 10.1016/j.bmc.2010.09.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation