3LXL

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

Summary for 3LXL

• Entry DOI: 10.2210/pdb3lxl/pdb
• Related: 1YVJ 2B7A 3EYG 3EYH 3FUP 3LXK 3LXN 3LXP
• Descriptor: Tyrosine-protein kinase JAK3, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (3 entities in total)
• Functional Keywords: tyk2, jak3, inflammation, cancer, pan inhibitor, atp-binding, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, scid, sh2 domain, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Endomembrane system; Peripheral membrane protein (By similarity): P52333
• Total number of polymer chains: 1
• Total formula weight: 37502.74

Authors

Chrencik, J.E.,Benson, T.E. (deposition date: 2010-02-25, release date: 2010-06-02, Last modification date: 2023-09-06)

• Primary citation: Chrencik, J.E.,Patny, A.,Leung, I.K.,Korniski, B.,Emmons, T.L.,Hall, T.,Weinberg, R.A.,Gormley, J.A.,Williams, J.M.,Day, J.E.,Hirsch, J.L.,Kiefer, J.R.,Leone, J.W.,Fischer, H.D.,Sommers, C.D.,Huang, H.C.,Jacobsen, E.J.,Tenbrink, R.E.,Tomasselli, A.G.,Benson, T.E.; Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.; J.Mol.Biol., 400:413-433, 2010; PubMed: 20478313; DOI: 10.1016/j.jmb.2010.05.020

Experimental method

X-RAY DIFFRACTION (1.74 Å)