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3LXK

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

Summary for 3LXK
Entry DOI10.2210/pdb3lxk/pdb
Related1YVJ 2B7A 3EYG 3EYH 3FUP 3LXL 3LXN 3LXP
DescriptorTyrosine-protein kinase JAK3, 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile (3 entities in total)
Functional Keywordstyk2, jak3, inflammation, cancer, pan inhibitor, atp-binding, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, scid, sh2 domain, transferase, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationEndomembrane system; Peripheral membrane protein (By similarity): P52333
Total number of polymer chains1
Total formula weight37505.78
Authors
Chrencik, J.E.,Patny, A.,Leung, I.K.,Korniski, B.,Emmons, T.L.,Benson, T.E. (deposition date: 2010-02-25, release date: 2010-06-02, Last modification date: 2023-09-06)
Primary citationChrencik, J.E.,Patny, A.,Leung, I.K.,Korniski, B.,Emmons, T.L.,Hall, T.,Weinberg, R.A.,Gormley, J.A.,Williams, J.M.,Day, J.E.,Hirsch, J.L.,Kiefer, J.R.,Leone, J.W.,Fischer, H.D.,Sommers, C.D.,Huang, H.C.,Jacobsen, E.J.,Tenbrink, R.E.,Tomasselli, A.G.,Benson, T.E.
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J.Mol.Biol., 400:413-433, 2010
Cited by
PubMed: 20478313
DOI: 10.1016/j.jmb.2010.05.020
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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