3LQG
Human aldose reductase mutant T113A complexed with IDD388
Summary for 3LQG
Entry DOI | 10.2210/pdb3lqg/pdb |
Related | 1US0 2IKI 3LBO 3LD5 3LEP 3LQL 3LZ3 3LZ5 3M4H |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID, ... (5 entities in total) |
Functional Keywords | t113a mutant, oxidoreductase, nadp, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37108.25 |
Authors | |
Primary citation | Koch, C.,Heine, A.,Klebe, G. Tracing the detail: how mutations affect binding modes and thermodynamic signatures of closely related aldose reductase inhibitors J.Mol.Biol., 406:700-712, 2011 Cited by PubMed: 21185307DOI: 10.1016/j.jmb.2010.11.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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