3LMG

Crystal structure of the ERBB3 kinase domain in complex with AMP-PNP

Summary for 3LMG

Entry DOI	10.2210/pdb3lmg/pdb
Descriptor	Receptor tyrosine-protein kinase erbB-3, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	erbb3, her3, tyrosine kinase domain, amp-pnp, nucleotide binding, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860
Total number of polymer chains	2
Total formula weight	78528.14
Authors	Shi, F.,Lemmon, M.A. (deposition date: 2010-01-30, release date: 2010-04-21, Last modification date: 2023-09-06)
Primary citation	Shi, F.,Telesco, S.E.,Liu, Y.,Radhakrishnan, R.,Lemmon, M.A. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proc.Natl.Acad.Sci.USA, 107:7692-7697, 2010 Cited by PubMed: 20351256 DOI: 10.1073/pnas.1002753107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation