3LC4

Human Cytochrome P450 2E1 in Complex with Omega-Imidazolyl-Dodecanoic Acid

Summary for 3LC4

Entry DOI	10.2210/pdb3lc4/pdb
Related	3E4E 3E6I 3GPH 3KOH
Descriptor	Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE, 12-(1H-imidazol-1-yl)dodecanoic acid, ... (4 entities in total)
Functional Keywords	cyp2e1, p450 2e1, monooxygenase, acetaminophen, heme, endoplasmic reticulum, iron, membrane, metal-binding, microsome, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P05181
Total number of polymer chains	2
Total formula weight	111882.71
Authors	Scott, E.E.,Porubsky, P.R. (deposition date: 2010-01-09, release date: 2010-05-12, Last modification date: 2023-09-06)
Primary citation	Porubsky, P.R.,Battaile, K.P.,Scott, E.E. Human cytochrome P450 2E1 structures with fatty acid analogs reveal a previously unobserved binding mode. J.Biol.Chem., 285:22282-22290, 2010 Cited by PubMed: 20463018 DOI: 10.1074/jbc.M110.109017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation