3L81

Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)

Summary for 3L81

Entry DOI	10.2210/pdb3l81/pdb
Related	1BW8 1BXX 3G9H
Descriptor	AP-4 complex subunit mu-1, Amyloid beta A4 protein, GLYCEROL, ... (4 entities in total)
Functional Keywords	immunoglobulin-like beta-sandwich, coated pit, golgi apparatus, membrane, phosphoprotein, protein transport, transport, alzheimer disease, amyloid, amyloidosis, transport protein
Biological source	Homo sapiens (human)
Cellular location	Golgi apparatus, trans-Golgi network : O00189 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	2
Total formula weight	34351.99
Authors	Mardones, G.A.,Rojas, A.L.,Burgos, P.V.,Dasilva, L.L.P.,Prabhu, Y.,Bonifacino, J.S.,Hurley, J.H. (deposition date: 2009-12-29, release date: 2010-06-02, Last modification date: 2024-02-21)
Primary citation	Burgos, P.V.,Mardones, G.A.,Rojas, A.L.,daSilva, L.L.,Prabhu, Y.,Hurley, J.H.,Bonifacino, J.S. Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev.Cell, 18:425-436, 2010 Cited by PubMed: 20230749 DOI: 10.1016/j.devcel.2010.01.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation