3L6F

Structure of MHC class II molecule HLA-DR1 complexed with phosphopeptide MART-1

Summary for 3L6F

Entry DOI	10.2210/pdb3l6f/pdb
Descriptor	HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, Melanoma antigen recognized by T-cells 1, ... (4 entities in total)
Functional Keywords	mhc class ii, hla-dr1, phosphopeptide, disulfide bond, glycoprotein, immune response, membrane, mhc ii, transmembrane, endoplasmic reticulum, golgi apparatus, immune system-peptide binding protein complex, immune system/peptide binding protein
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P01903 P04229 Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
Total number of polymer chains	3
Total formula weight	45267.73
Authors	Li, Y.,Mariuzza, R.A. (deposition date: 2009-12-23, release date: 2010-05-12, Last modification date: 2023-09-06)
Primary citation	Li, Y.,Depontieu, F.R.,Sidney, J.,Salay, T.M.,Engelhard, V.H.,Hunt, D.F.,Sette, A.,Topalian, S.L.,Mariuzza, R.A. Structural Basis for the Presentation of Tumor-Associated MHC Class II-Restricted Phosphopeptides to CD4(+) T Cells. J.Mol.Biol., 399:596-603, 2010 Cited by PubMed: 20417641 DOI: 10.1016/j.jmb.2010.04.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation