3L4X

Crystal complex of N-terminal Human Maltase-Glucoamylase with NR4-8

Summary for 3L4X

Entry DOI	10.2210/pdb3l4x/pdb
Related	3L4T 3L4U 3L4V 3L4W 3L4Y 3L4Z
Descriptor	Maltase-glucoamylase, intestinal, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate, ... (6 entities in total)
Functional Keywords	glycoside hydrolase family 31, cell membrane, disulfide bond, glycoprotein, glycosidase, hydrolase, membrane, multifunctional enzyme, polymorphism, signal-anchor, sulfation, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Apical cell membrane; Single-pass type II membrane protein: O43451
Total number of polymer chains	1
Total formula weight	100715.17
Authors	Sim, L.,Rose, D.R. (deposition date: 2009-12-21, release date: 2010-02-09, Last modification date: 2020-07-29)
Primary citation	Sim, L.,Jayakanthan, K.,Mohan, S.,Nasi, R.,Johnston, B.D.,Pinto, B.M.,Rose, D.R. New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata. Biochemistry, 49:443-451, 2010 Cited by PubMed: 20039683 DOI: 10.1021/bi9016457 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation