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3L3L

PARP complexed with A906894

Summary for 3L3L
Entry DOI10.2210/pdb3l3l/pdb
Related2RCW 2RD6 3GJW 3GN7
DescriptorPoly [ADP-ribose] polymerase 1, 3-oxo-2-piperidin-4-yl-2,3-dihydro-1H-isoindole-4-carboxamide (3 entities in total)
Functional Keywordsprotein-inhibitor complex, adp-ribosylation, dna damage, dna repair, dna-binding, glycosyltransferase, metal-binding, nad, nucleus, phosphoprotein, transcription, transcription regulation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P09874
Total number of polymer chains1
Total formula weight39428.11
Authors
Park, C.H. (deposition date: 2009-12-17, release date: 2010-12-22, Last modification date: 2024-02-21)
Primary citationGandhi, V.B.,Luo, Y.,Liu, X.,Shi, Y.,Klinghofer, V.,Johnson, E.F.,Park, C.,Giranda, V.L.,Penning, T.D.,Zhu, G.D.
Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Bioorg.Med.Chem.Lett., 20:1023-1026, 2010
Cited by
PubMed: 20045315
DOI: 10.1016/j.bmcl.2009.12.042
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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