3L33

Human mesotrypsin complexed with amyloid precursor protein inhibitor(APPI)

Summary for 3L33

Entry DOI	10.2210/pdb3l33/pdb
Related	1ZJD 2R9P
Descriptor	Trypsin-3, Amyloid beta A4 protein, FORMIC ACID, ... (5 entities in total)
Functional Keywords	human mesotrypsin, alzheimer's amyloid precursor protein inhibitor, appi, serine protease inhibitor, hydrolase-cell adhesion complex, hydrolase/cell adhesion
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P35030 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	8
Total formula weight	121342.62
Authors	Salameh, M.A.,Soares, A.S.,Radisky, E.S. (deposition date: 2009-12-16, release date: 2010-09-22, Last modification date: 2011-07-13)
Primary citation	Salameh, M.A.,Soares, A.S.,Navaneetham, D.,Sinha, D.,Walsh, P.N.,Radisky, E.S. Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin. J.Biol.Chem., 285:36884-36896, 2010 Cited by PubMed: 20861008 DOI: 10.1074/jbc.M110.171348 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.48 Å)

Structure validation