3L2J

Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor (PTH1R)

Summary for 3L2J

Entry DOI	10.2210/pdb3l2j/pdb
Related	3C4M 3H3G
Related PRD ID	PRD_900001
Descriptor	Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (2 entities in total)
Functional Keywords	dimer, extracellular domain, mbp fusion protein, periplasm, sugar transport, transport, cell membrane, disease mutation, disulfide bond, dwarfism, g-protein coupled receptor, glycoprotein, membrane, receptor, transducer, transmembrane, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	2
Total formula weight	120391.27
Authors	Pioszak, A.A.,Xu, H.E. (deposition date: 2009-12-15, release date: 2010-02-02, Last modification date: 2023-09-06)
Primary citation	Pioszak, A.A.,Harikumar, K.G.,Parker, N.R.,Miller, L.J.,Xu, H.E. Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation. J.Biol.Chem., 285:12435-12444, 2010 Cited by PubMed: 20172855 DOI: 10.1074/jbc.M109.093138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.24 Å)

Structure validation