3L29

Crystal Structure of Zaire Ebola VP35 interferon inhibitory domain K319A/R322A mutant

Summary for 3L29

Entry DOI	10.2210/pdb3l29/pdb
Related	3FKE 3L25 3L26 3L27 3L28 3L2A
Descriptor	Polymerase cofactor VP35, CHLORIDE ION (3 entities in total)
Functional Keywords	rna binding domain, interferon antiviral evasion, rna replication, rna binding protein, transcription, host cytoplasm, interferon antiviral system evasion, rna-binding, virion
Biological source	Zaire ebolavirus (ZEBOV)
Cellular location	Virion: Q05127
Total number of polymer chains	2
Total formula weight	28203.52
Authors	Leung, D.W.,Ramanan, P.,Borek, D.M.,Amarasinghe, G.K. (deposition date: 2009-12-14, release date: 2010-02-02, Last modification date: 2023-09-06)
Primary citation	Prins, K.C.,Delpeut, S.,Leung, D.W.,Reynard, O.,Volchkova, V.A.,Reid, S.P.,Ramanan, P.,Cardenas, W.B.,Amarasinghe, G.K.,Volchkov, V.E.,Basler, C.F. Mutations abrogating VP35 interaction with double-stranded RNA render ebola virus avirulent in guinea pigs. J.Virol., 84:3004-3015, 2010 Cited by PubMed: 20071589 DOI: 10.1128/JVI.02459-09 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation