3L26

Crystal structure of Zaire Ebola VP35 interferon inhibitory domain bound to 8 bp dsRNA

Summary for 3L26

• Entry DOI: 10.2210/pdb3l26/pdb
• Related: 3FKE 3L25 3L27 3L28 3L29 3L2A
• Descriptor: Polymerase cofactor VP35, RNA (5'-R(*CP*GP*CP*AP*UP*GP*CP*G)-3'), MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: rna binding domain, interferon antiviral evasion, rna replication, rna binding protein, transcription, host cytoplasm, interferon antiviral system evasion, rna-binding, virion, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Zaire ebolavirus (ZEBOV)
• Cellular location: Virion: Q05127
• Total number of polymer chains: 3
• Total formula weight: 31261.41

Authors

Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K. (deposition date: 2009-12-14, release date: 2010-01-26, Last modification date: 2023-09-06)

• Primary citation: Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K.; Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35.; Nat.Struct.Mol.Biol., 17:165-172, 2010; PubMed: 20081868; DOI: 10.1038/nsmb.1765

Experimental method

X-RAY DIFFRACTION (2.4 Å)