3L1S

3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3

Summary for 3L1S

• Entry DOI: 10.2210/pdb3l1s/pdb
• Descriptor: Glycogen synthase kinase-3 beta, (4E)-4-[(4-chlorophenyl)hydrazono]-5-(3,4-dimethoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: kinase, pyrazole, gsk3, atp-binding, nucleotide-binding, serine/threonine-protein kinase, wnt signaling pathway, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 93041.31

Authors

Haar, T.E. (deposition date: 2009-12-14, release date: 2010-03-02, Last modification date: 2024-04-03)

• Primary citation: Arnost, M.,Pierce, A.,Haar, E.T.,Lauffer, D.,Madden, J.,Tanner, K.,Green, J.; 3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3beta.; Bioorg.Med.Chem.Lett., 20:1661-1664, 2010; PubMed: 20138514; DOI: 10.1016/j.bmcl.2010.01.072

Experimental method

X-RAY DIFFRACTION (2.9 Å)