3KYC

Human SUMO E1 complex with a SUMO1-AMP mimic

Summary for 3KYC

• Entry DOI: 10.2210/pdb3kyc/pdb
• Related: 3KYD
• Descriptor: SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, Small ubiquitin-related modifier 1, ... (6 entities in total)
• Functional Keywords: e1, sumo, ubiquitin, thioester, adenylation, inhibitor, acyl-adenylate intermediate, acetylation, ligase, nucleus, phosphoprotein, ubl conjugation pathway, atp-binding, nucleotide-binding, polymorphism, cytoplasm, isopeptide bond, membrane
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q9UBE0; Cytoplasm: Q9UBT2; Nucleus membrane: P63165
• Total number of polymer chains: 3
• Total formula weight: 123564.07

Authors

Lima, C.D. (deposition date: 2009-12-05, release date: 2010-02-16, Last modification date: 2024-03-13)

• Primary citation: Olsen, S.K.,Capili, A.D.,Lu, X.,Tan, D.S.,Lima, C.D.; Active site remodelling accompanies thioester bond formation in the SUMO E1.; Nature, 463:906-912, 2010; PubMed: 20164921; DOI: 10.1038/nature08765

Experimental method

X-RAY DIFFRACTION (2.45 Å)