3KUC

Complex of Rap1A(E30D/K31E)GDP with RafRBD(A85K/N71R)

Summary for 3KUC

Entry DOI	10.2210/pdb3kuc/pdb
Related	3KUD
Descriptor	Ras-related protein Rap-1A, RAF proto-oncogene serine/threonine-protein kinase, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	ras-effector complex, gtp-binding, nucleotide-binding, proto-oncogene, transferase, gtp binding protein-transferase complex, gtp binding protein/transferase
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane ; Lipid-anchor : P62834 Cytoplasm: P04049
Total number of polymer chains	2
Total formula weight	28854.09
Authors	Filchtinski, D.,Sharabi, O.,Rueppel, A.,Vetter, I.R.,Herrmann, C.,Shifman, J.M. (deposition date: 2009-11-27, release date: 2010-03-23, Last modification date: 2023-09-06)
Primary citation	Filchtinski, D.,Sharabi, O.,Ruppel, A.,Vetter, I.R.,Herrmann, C.,Shifman, J.M. What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf. J.Mol.Biol., 399:422-435, 2010 Cited by PubMed: 20361980 DOI: 10.1016/j.jmb.2010.03.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation