3KSQ

Discovery of C-Imidazole Azaheptapyridine FPT Inhibitors

Summary for 3KSQ

Entry DOI	10.2210/pdb3ksq/pdb
Descriptor	Farnesyltransferase, CAAX box, alpha, Protein farnesyltransferase subunit beta, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	prenyltransferase, metal-binding, phosphoprotein, transferase
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	93802.45
Authors	Zhu, H.Y.,Cooper, A.B.,Njoroge, G.,Kirschmeier, P.,Strickland, C.,Hruza, A.,Girijavallabhan, V.M. (deposition date: 2009-11-23, release date: 2010-01-26, Last modification date: 2023-09-06)
Primary citation	Zhu, H.Y.,Cooper, A.B.,Desai, J.,Njoroge, G.,Kirschmeier, P.,Bishop, W.R.,Strickland, C.,Hruza, A.,Doll, R.J.,Girijavallabhan, V.M. Discovery of C-imidazole azaheptapyridine FPT inhibitors. Bioorg.Med.Chem.Lett., 20:1134-1136, 2010 Cited by PubMed: 20056542 DOI: 10.1016/j.bmcl.2009.12.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation