3KS8

Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA

Summary for 3KS8

• Entry DOI: 10.2210/pdb3ks8/pdb
• Related: 3FKE 3KS4
• Descriptor: 5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3', 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3', Polymerase cofactor VP35, ... (4 entities in total)
• Functional Keywords: ebolavirus, rna-binding protein, protein-rna complex, interferon, reston, host cytoplasm, interferon antiviral system evasion, rna replication, rna-binding, transcription, virion, viral protein-rna complex, viral protein/rna
• Biological source: Reston ebolavirus (REBOV)
• Cellular location: Virion: Q8JPY0
• Total number of polymer chains: 6
• Total formula weight: 93789.65

Authors

Kimberlin, C.R.,Bornholdt, Z.A.,Li, S.,Woods, V.L.,Macrae, I.J.,Saphire, E.O. (deposition date: 2009-11-20, release date: 2010-01-12, Last modification date: 2023-09-06)

• Primary citation: Kimberlin, C.R.,Bornholdt, Z.A.,Li, S.,Woods, V.L.,Macrae, I.J.,Saphire, E.O.; Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.; Proc.Natl.Acad.Sci.USA, 107:314-319, 2009; PubMed: 20018665; DOI: 10.1073/pnas.0910547107

Experimental method

X-RAY DIFFRACTION (2.401 Å)