3KRQ

Crystal structure of the complex of lactoperoxidase with a potent inhibitor amino-triazole at 2.2a resolution

Summary for 3KRQ

• Entry DOI: 10.2210/pdb3krq/pdb
• Related: 3GC1
• Descriptor: Lactoperoxidase, DI(HYDROXYETHYL)ETHER, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: heme, peroxidase, complex, antibiotic, antimicrobial, cleavage on pair of basic residues, disulfide bond, glycoprotein, hydrogen peroxide, iron, metal-binding, secreted, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Bos taurus (bovine)
• Total number of polymer chains: 1
• Total formula weight: 71974.65

Authors

Singh, A.K.,Singh, N.,Sinha, M.,Kushwaha, G.S.,Kaur, P.,Srinivasan, A.,Sharma, S.,Singh, T.P. (deposition date: 2009-11-19, release date: 2010-05-26, Last modification date: 2023-11-01)

• Primary citation: Singh, A.K.,Singh, N.,Tiwari, A.,Sinha, M.,Kushwaha, G.S.,Kaur, P.,Srinivasan, A.,Sharma, S.,Singh, T.P.; First structural evidence for the mode of diffusion of aromatic ligands and ligand-induced closure of the hydrophobic channel in heme peroxidases; J.Biol.Inorg.Chem., 15:1099-1107, 2010; PubMed: 20461536; DOI: 10.1007/s00775-010-0669-3

Experimental method

X-RAY DIFFRACTION (2.25 Å)