3KR3

Crystal structure of IGF-II antibody complex

Summary for 3KR3

Entry DOI	10.2210/pdb3kr3/pdb
Descriptor	Insulin-like growth factor II, antibody-Fab (heavy chain), antibody-Fab (light chain), ... (5 entities in total)
Functional Keywords	antibody-target complex, carbohydrate metabolism, glucose metabolism, glycoprotein, growth factor, hormone, mitogen, osteogenesis, secreted, immune system
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P01344
Total number of polymer chains	3
Total formula weight	57898.48
Authors	Peat, T.S.,Newman, J.,Adams, T.E. (deposition date: 2009-11-17, release date: 2010-06-16, Last modification date: 2011-07-13)
Primary citation	Dransfield, D.T.,Cohen, E.H.,Chang, Q.,Sparrow, L.G.,Bentley, J.D.,Dolezal, O.,Xiao, X.,Peat, T.S.,Newman, J.,Pilling, P.A.,Phan, T.,Priebe, I.,Brierley, G.V.,Kastrapeli, N.,Kopacz, K.,Martik, D.,Wassaf, D.,Rank, D.,Conley, G.,Huang, Y.,Adams, T.E.,Cosgrove, L. A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Mol.Cancer Ther., 9:1809-1819, 2010 Cited by PubMed: 20515953 DOI: 10.1158/1535-7163.MCT-09-1134 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation