3KPW

Crystal Structure of hPNMT in Complex AdoHcy and 1-Aminoisoquinoline

Summary for 3KPW

Entry DOI	10.2210/pdb3kpw/pdb
Related	3KPJ 3KPU 3KPV 3KPY 3KQM 3KQO 3KQP 3KQQ 3KQS 3KQT 3KQV 3KQW 3KQY 3KR0 3KR1 3KR2
Descriptor	Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ISOQUINOLIN-1-AMINE, ... (4 entities in total)
Functional Keywords	methyltransferase, fragment screening, catecholamine biosynthesis, s-adenosyl-l-methionine, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	64749.10
Authors	Drinkwater, N.,Martin, J.L. (deposition date: 2009-11-17, release date: 2010-09-29, Last modification date: 2023-09-06)
Primary citation	Drinkwater, N.,Vu, H.,Lovell, K.M.,Criscione, K.R.,Collins, B.M.,Prisinzano, T.E.,Poulsen, S.A.,McLeish, M.J.,Grunewald, G.L.,Martin, J.L. Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem.J., 431:51-61, 2010 Cited by PubMed: 20642456 DOI: 10.1042/BJ20100651 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation