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3KMR

Crystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment

Summary for 3KMR
Entry DOI10.2210/pdb3kmr/pdb
DescriptorRetinoic acid receptor alpha, Nuclear receptor coactivator 1, 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, ... (4 entities in total)
Functional Keywordsnuclear receptor transcription factor ligand binding domain, dna-binding, metal-binding, nucleus, phosphoprotein, proto-oncogene, receptor, transcription, transcription regulation, zinc-finger, activator, acyltransferase, isopeptide bond, transferase
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus: P10276
Nucleus (By similarity): Q15788
Total number of polymer chains2
Total formula weight31910.91
Authors
Bourguet, W.,Teyssier, C. (deposition date: 2009-11-11, release date: 2010-06-02, Last modification date: 2023-09-06)
Primary citationle Maire, A.,Teyssier, C.,Erb, C.,Grimaldi, M.,Alvarez, S.,de Lera, A.R.,Balaguer, P.,Gronemeyer, H.,Royer, C.A.,Germain, P.,Bourguet, W.
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
Nat.Struct.Mol.Biol., 17:801-807, 2010
Cited by
PubMed: 20543827
DOI: 10.1038/nsmb.1855
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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