3KMG

The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide

Summary for 3KMG

• Entry DOI: 10.2210/pdb3kmg/pdb
• Related: 1fm6 1fm9 1prg 2prg
• Descriptor: Peroxisome proliferator-activated receptor gamma, Steroid Receptor Coactivator-1, 4'-[(2,3-dimethyl-5-{[(1S)-1-phenylpropyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid, ... (4 entities in total)
• Functional Keywords: ppar-gamma, peroxisome proliferator-activated receptor, telmisartan, diabetes, modulator, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 4
• Total formula weight: 68881.94

Authors

Gampe, R. (deposition date: 2009-11-10, release date: 2010-01-12, Last modification date: 2024-03-13)

• Primary citation: Lamotte, Y.,Martres, P.,Faucher, N.,Laroze, A.,Grillot, D.,Ancellin, N.,Saintillan, Y.,Beneton, V.,Gampe, R.; Synthesis and biological activities of novel indole derivatives as potent and selective PPAR-gamma modulators; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.1 Å)