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3KGU

Wild type human transthyretin (TTR) complexed with genistein (TTRwt:GEN) pH 7.5

Summary for 3KGU
Entry DOI10.2210/pdb3kgu/pdb
Related3KGS 3KGT
DescriptorTransthyretin, GENISTEIN (3 entities in total)
Functional Keywordstransport protein, ttr, transthyretin, amyloid, amyloidosis, cytoplasm, disease mutation, hormone, neuropathy, polymorphism, secreted, thyroid hormone, transport
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28095.19
Authors
Trivella, D.B.,Polikarpov, I. (deposition date: 2009-10-29, release date: 2010-03-23, Last modification date: 2024-02-21)
Primary citationTrivella, D.B.,Bleicher, L.,Palmieri, L.C.,Wiggers, H.J.,Montanari, C.A.,Kelly, J.W.,Lima, L.M.,Foguel, D.,Polikarpov, I.
Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding.
J.Struct.Biol., 170:522-531, 2010
Cited by
PubMed: 20211733
DOI: 10.1016/j.jsb.2010.03.002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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