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3KFN

HIV Protease (PR) with inhibitor TL-3 and fragment hit 4D9 by soaking

Summary for 3KFN
Entry DOI10.2210/pdb3kfn/pdb
Related2AZ8 3KF0 3KF1 3KFP 3KFR 3KFS
Related PRD IDPRD_000434
DescriptorProtease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, (1S,2S)-2-methylcyclohexanol, ... (7 entities in total)
Functional Keywordshiv-1, protease, exo site, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight23155.79
Authors
Stout, C.D. (deposition date: 2009-10-27, release date: 2010-02-23, Last modification date: 2023-09-06)
Primary citationPerryman, A.L.,Zhang, Q.,Soutter, H.H.,Rosenfeld, R.,McRee, D.E.,Olson, A.J.,Elder, J.E.,David Stout, C.
Fragment-based screen against HIV protease.
Chem.Biol.Drug Des., 75:257-268, 2010
Cited by
PubMed: 20659109
DOI: 10.1111/j.1747-0285.2009.00943.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.77 Å)
Structure validation

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