3KF7

Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound

Summary for 3KF7

Entry DOI	10.2210/pdb3kf7/pdb
Descriptor	Mitogen-activated protein kinase 14, 3-{6-[2-(2,4-difluorophenyl)ethyl][1,2,4]triazolo[4,3-a]pyridin-3-yl}-4-methylbenzamide (3 entities in total)
Functional Keywords	two lobes, atp pocket, peptide flip, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	41735.60
Authors	Shieh, H.-S.,Williams, J.M.,Stegeman, R.A.,Xing, L.,Jerome, K.D. (deposition date: 2009-10-27, release date: 2009-12-29, Last modification date: 2024-02-21)
Primary citation	Jerome, K.D.,Rucker, P.V.,Xing, L.,Shieh, H.S.,Baldus, J.E.,Selness, S.R.,Letavic, M.A.,Braganza, J.F.,McClure, K.F. Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition. Bioorg.Med.Chem.Lett., 20:469-473, 2010 Cited by PubMed: 19969459 DOI: 10.1016/j.bmcl.2009.11.114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation