3KE0

Crystal structure of N370S Glucocerebrosidase at acidic pH.

Summary for 3KE0

• Entry DOI: 10.2210/pdb3ke0/pdb
• Related: 3KEH
• Descriptor: Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: tim barrel, alternative initiation, disease mutation, disulfide bond, gaucher disease, glycoprotein, glycosidase, hydrolase, ichthyosis, lipid metabolism, lysosome, membrane, sphingolipid metabolism
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 113859.50

Authors

Wei, R.R.,Boucher, S.,Pan, C.Q.,Edmunds, T. (deposition date: 2009-10-23, release date: 2010-10-27, Last modification date: 2023-09-06)

• Primary citation: Wei, R.R.,Boucher, S.,Hughes, H.,Guziewica, N.,Pan, C.Q.,Edmunds, T.; Crystal Structure of Glucocerebrosidase Containing the N370S Mutation, Implications for Chaperon Therapy; To be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)