3KC0

Crystal structure of human liver FBPase in complex with tricyclic inhibitor 10b

Summary for 3KC0

Entry DOI	10.2210/pdb3kc0/pdb
Related	3KBZ 3KC1
Descriptor	Fructose-1,6-bisphosphatase 1, [(8H-indeno[1,2-d][1,3]thiazol-4-yloxy)methyl]phosphonic acid (3 entities in total)
Functional Keywords	hydrolase, allosteric enzyme, carbohydrate metabolism, disease mutation, gluconeogenesis, magnesium, metal-binding, polymorphism
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	148045.87
Authors	Takahashi, M.,Sone, J.,Hanzawa, H. (deposition date: 2009-10-20, release date: 2010-02-02, Last modification date: 2023-11-01)
Primary citation	Tsukada, T.,Takahashi, M.,Takemoto, T.,Kanno, O.,Yamane, T.,Kawamura, S.,Nishi, T. Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20:1004-1007, 2010 Cited by PubMed: 20045638 DOI: 10.1016/j.bmcl.2009.12.056 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation