3K8S

Crystal Structure of PPARg in complex with T2384

Summary for 3K8S

Entry DOI	10.2210/pdb3k8s/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 2-chloro-N-{3-chloro-4-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]phenyl}-4-(trifluoromethyl)benzenesulfonamide (3 entities in total)
Functional Keywords	ppargamma, ligand binding pocket, ligand, diabetic, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, lbd and ligand binding domain
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	63897.83
Authors	Wang, Z. (deposition date: 2009-10-14, release date: 2009-11-03, Last modification date: 2023-09-06)
Primary citation	Li, Y.,Wang, Z.,Furukawa, N.,Escaron, P.,Weiszmann, J.,Lee, G.,Lindstrom, M.,Liu, J.,Liu, X.,Xu, H.,Plotnikova, O.,Prasad, V.,Walker, N.,Learned, R.M.,Chen, J.-L. T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties J.Biol.Chem., 283:9168-9176, 2008 Cited by PubMed: 18263587 DOI: 10.1074/jbc.M800104200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation