3K4F

X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone

Summary for 3K4F

• Entry DOI: 10.2210/pdb3k4f/pdb
• Related: 1N45 3CZY 3HOK
• Descriptor: Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 4-phenyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one, ... (6 entities in total)
• Functional Keywords: heme oxygenase-1 inhibitor complex, alpha helices, endoplasmic reticulum, heme, iron, metal-binding, microsome, oxidoreductase, phosphoprotein, polymorphism
• Biological source: Homo sapiens (human)
• Cellular location: Microsome: P09601
• Total number of polymer chains: 2
• Total formula weight: 55889.18

Authors

Rahman, M.N.,Jia, Z. (deposition date: 2009-10-05, release date: 2009-12-15, Last modification date: 2023-09-06)

• Primary citation: Roman, G.,Rahman, M.N.,Vukomanovic, D.,Jia, Z.,Nakatsu, K.,Szarek, W.A.; Heme Oxygenase Inhibition by 2-Oxy-substituted 1-Azolyl-4-phenylbutanes: Effect of Variation of the Azole Moiety. X-Ray Crystal Structure of Human Heme Oxygenase-1 in Complex with 4-Phenyl-1-(1H-1,2,4-triazol-1-yl)-2-butanone.; Chem.Biol.Drug Des., 75:68-90, 2010; PubMed: 19954435; DOI: 10.1111/j.1747-0285.2009.00909.x

Experimental method

X-RAY DIFFRACTION (2.17 Å)