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3K1W

New Classes of Potent and Bioavailable Human Renin Inhibitors

Summary for 3K1W
Entry DOI10.2210/pdb3k1w/pdb
DescriptorRenin, 4-{4-[3-(2-bromo-5-fluorophenoxy)propyl]phenyl}-N-(2-chlorobenzyl)-N-cyclopropyl-1,2,5,6-tetrahydropyridine-3-carboxamide, FORMIC ACID, ... (7 entities in total)
Functional Keywordsrenin, protease, alternative splicing, aspartyl protease, cleavage on pair of basic residues, disease mutation, disulfide bond, glycoprotein, hydrolase, membrane, polymorphism, secreted, zymogen
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P00797
Total number of polymer chains2
Total formula weight76576.11
Authors
Prade, L. (deposition date: 2009-09-29, release date: 2010-03-02, Last modification date: 2020-07-29)
Primary citationRemen, L.,Bezencon, O.,Richard-Bildstein, S.,Bur, D.,Prade, L.,Corminboeuf, O.,Boss, C.,Grisostomi, C.,Sifferlen, T.,Strickner, P.,Hess, P.,Delahaye, S.,Treiber, A.,Weller, T.,Binkert, C.,Steiner, B.,Fischli, W.
New classes of potent and bioavailable human renin inhibitors
Bioorg.Med.Chem.Lett., 19:6762-6765, 2009
Cited by
PubMed: 19853442
DOI: 10.1016/j.bmcl.2009.09.104
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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