3K15

Crystal Structure of BRCA1 BRCT D1840T in complex with a minimal recognition tetrapeptide with an amidated C-terminus

Summary for 3K15

Entry DOI	10.2210/pdb3k15/pdb
Related	3K05 3K0H 3K0K 3K15
Descriptor	Breast cancer type 1 susceptibility protein, phospho peptide, NICKEL (II) ION, ... (5 entities in total)
Functional Keywords	brca1, brct domain, dna damage response, phospho peptide interactions, bach1, alternative initiation, cell cycle, disease mutation, dna damage, dna repair, dna-binding, fatty acid biosynthesis, ligase, lipid synthesis, metal-binding, nucleus, phosphoprotein, tumor suppressor, ubl conjugation pathway, zinc-finger, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398
Total number of polymer chains	2
Total formula weight	25271.07
Authors	Campbell, S.J.,Edwards, R.A.,Glover, J.N. (deposition date: 2009-09-25, release date: 2010-03-02, Last modification date: 2021-10-13)
Primary citation	Campbell, S.J.,Edwards, R.A.,Glover, J.N. Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1 Structure, 18:167-176, 2010 Cited by PubMed: 20159462 DOI: 10.1016/j.str.2009.12.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation