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3JZK

crystal structure of MDM2 with chromenotriazolopyrimidine 1

Summary for 3JZK
Entry DOI10.2210/pdb3jzk/pdb
DescriptorE3 ubiquitin-protein ligase Mdm2, (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine (3 entities in total)
Functional Keywordsmdm2, p53, inhibitor, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains1
Total formula weight11692.27
Authors
Huang, X. (deposition date: 2009-09-23, release date: 2009-11-17, Last modification date: 2023-09-06)
Primary citationAllen, J.G.,Bourbeau, M.P.,Wohlhieter, G.E.,Bartberger, M.D.,Michelsen, K.,Hungate, R.,Gadwood, R.C.,Gaston, R.D.,Evans, B.,Mann, L.W.,Matison, M.E.,Schneider, S.,Huang, X.,Yu, D.,Andrews, P.S.,Reichelt, A.,Long, A.M.,Yakowec, P.,Yang, E.Y.,Lee, T.A.,Oliner, J.D.
Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.
J.Med.Chem., 52:7044-7053, 2009
Cited by
PubMed: 19856920
DOI: 10.1021/jm900681h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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