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3JQA

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-1,9-dihydro-6H-purine-6-thione (DX4)

Replaces:  3BMG
Summary for 3JQA
Entry DOI10.2210/pdb3jqa/pdb
Related3JQ6 3JQ7 3JQ8 3JQ9 3JQB 3JQC 3JQD 3JQE 3JQF 3JQG
DescriptorPteridine reductase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-amino-1,9-dihydro-6H-purine-6-thione, ... (6 entities in total)
Functional Keywordspteridine reductase, ptr1, trypanosoma brucei, short chain dehydrogenase, inhibitor, oxidoreductase
Biological sourceTrypanosoma brucei
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Total number of polymer chains4
Total formula weight126385.54
Authors
Tulloch, L.B.,Hunter, W.N. (deposition date: 2009-09-06, release date: 2009-12-08, Last modification date: 2023-09-06)
Primary citationTulloch, L.B.,Martini, V.P.,Iulek, J.,Huggan, J.K.,Lee, J.H.,Gibson, C.L.,Smith, T.K.,Suckling, C.J.,Hunter, W.N.
Structure-based design of pteridine reductase inhibitors targeting african sleeping sickness and the leishmaniases.
J.Med.Chem., 53:221-229, 2010
Cited by
PubMed: 19916554
DOI: 10.1021/jm901059x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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