3J70

Model of gp120, including variable regions, in complex with CD4 and 17b

Summary for 3J70

• Entry DOI: 10.2210/pdb3j70/pdb
• EMDB information: 5020
• Descriptor: monoclonal antibody 17b light chain, monoclonal antibody 17b heavy chain, T-cell surface glycoprotein CD4, ... (5 entities in total)
• Functional Keywords: gp120, v1v2, cd4, 17b, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: P01730; Cell membrane ; Single-pass type I membrane protein : P04578
• Total number of polymer chains: 15
• Total formula weight: 391383.66

Authors

Rasheed, M.,Bettadapura, R.,Bajaj, C. (deposition date: 2014-04-22, release date: 2015-08-26)

• Primary citation: Rasheed, M.,Bettadapura, R.,Bajaj, C.; Computational Refinement and Validation Protocol for Proteins with Large Variable Regions Applied to Model HIV Env Spike in CD4 and 17b Bound State.; Structure, 23:1138-1149, 2015; PubMed: 26039348; DOI: 10.1016/j.str.2015.03.026

Experimental method

ELECTRON MICROSCOPY (20 Å)