3ITZ

Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor

Summary for 3ITZ

Entry DOI	10.2210/pdb3itz/pdb
Related	1YQJ 3DS6 3DT1 3GFE
Descriptor	Mitogen-activated protein kinase 14, 4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-d]pyridazin-4-yl]amino}benzamide (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, transferase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	42439.77
Authors	Mohr, C.,Jordan, S. (deposition date: 2009-08-28, release date: 2010-03-02, Last modification date: 2024-02-21)
Primary citation	Wurz, R.P.,Pettus, L.H.,Henkle, B.,Sherman, L.,Plant, M.,Miner, K.,McBride, H.J.,Wong, L.M.,Saris, C.J.,Lee, M.R.,Chmait, S.,Mohr, C.,Hsieh, F.,Tasker, A.S. Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg.Med.Chem.Lett., 20:1680-1684, 2010 Cited by PubMed: 20138761 DOI: 10.1016/j.bmcl.2010.01.059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation