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3ISW

Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR

Summary for 3ISW
Entry DOI10.2210/pdb3isw/pdb
DescriptorFilamin-A, Cystic fibrosis transmembrane conductance regulator (3 entities in total)
Functional Keywordsprotein-peptide complex, acetylation, actin-binding, alternative splicing, cytoplasm, cytoskeleton, disease mutation, phosphoprotein, polymorphism, atp-binding, chloride, chloride channel, glycoprotein, hydrolase, ion transport, ionic channel, membrane, nucleotide-binding, transmembrane, transport, structural protein
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm, cell cortex: P21333
Early endosome membrane; Multi-pass membrane protein: P13569
Total number of polymer chains3
Total formula weight22363.74
Authors
Xu, Z.,Page, R.,Qin, J.,Ithychanda, S.S.,Liu, J.M.,Misra, S. (deposition date: 2009-08-27, release date: 2010-04-07, Last modification date: 2023-09-06)
Primary citationSmith, L.,Page, R.C.,Xu, Z.,Kohli, E.,Litman, P.,Nix, J.C.,Ithychanda, S.S.,Liu, J.,Qin, J.,Misra, S.,Liedtke, C.M.
Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin.
J.Biol.Chem., 285:17166-17176, 2010
Cited by
PubMed: 20351101
DOI: 10.1074/jbc.M109.080911
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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