3IQS

Crystal structure of the anti-viral APOBEC3G catalytic domain

Summary for 3IQS

Entry DOI	10.2210/pdb3iqs/pdb
Related	3E1U
Descriptor	DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION (3 entities in total)
Functional Keywords	five beta-strands surrounded by six alpha-helices, alternative splicing, antiviral defense, cytoplasm, host-virus interaction, hydrolase, metal-binding, nucleus, polymorphism, ubl conjugation, zinc
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9HC16
Total number of polymer chains	1
Total formula weight	22153.40
Authors	Holden, L.G.,Prochnow, C.,Chang, Y.P.,Bransteitter, R.,Chelico, L.,Sen, U.,Stevens, R.C.,Goodman, R.F.,Chen, X.S. (deposition date: 2009-08-20, release date: 2009-11-10, Last modification date: 2024-02-21)
Primary citation	Holden, L.G.,Prochnow, C.,Chang, Y.P.,Bransteitter, R.,Chelico, L.,Sen, U.,Stevens, R.C.,Goodman, M.F.,Chen, X.S. Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature, 456:121-124, 2008 Cited by PubMed: 18849968 DOI: 10.1038/nature07357 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation