3IPU

X-ray structure of benzisoxazole urea synthetic agonist bound to the LXR-alpha

Summary for 3IPU

• Entry DOI: 10.2210/pdb3ipu/pdb
• Related: 3IPQ 3IPS
• Descriptor: Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, 4-{[methyl(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)carbamoyl]amino}benzoic acid, ... (5 entities in total)
• Functional Keywords: nuclear receptor, lxr homodimer, lxr signaling, alternative splicing, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, chromosomal rearrangement, isopeptide bond, phosphoprotein, proto-oncogene, transferase, ubl conjugation
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Potential): Q13133; Nucleus (By similarity): Q15788
• Total number of polymer chains: 4
• Total formula weight: 72496.13

Authors

Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wijnands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennet, D.J.,McGuire, R.,Uitdehaag, J.C.M. (deposition date: 2009-08-18, release date: 2010-06-02, Last modification date: 2024-04-03)

• Primary citation: Fradera, X.,Vu, D.,Nimz, O.,Skene, R.,Hosfield, D.,Wynands, R.,Cooke, A.J.,Haunso, A.,King, A.,Bennett, D.J.,McGuire, R.,Uitdehaag, J.C.; X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.; J.Mol.Biol., 399:120-132, 2010; PubMed: 20382159; DOI: 10.1016/j.jmb.2010.04.005

Experimental method

X-RAY DIFFRACTION (2.4 Å)