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3IPE

Human Transthyretin (TTR) complexed with a palindromic bivalent amyloid inhibitor (7 carbon linker).

Summary for 3IPE
Entry DOI10.2210/pdb3ipe/pdb
Related3IPB 3IPG
DescriptorTransthyretin, 2,2'-{heptane-1,7-diylbis[oxy(3,5-dichlorobenzene-4,1-diyl)imino]}dibenzoic acid (3 entities in total)
Functional Keywordsamyloid, inhibitor, palindrome, amyloidosis, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, neuropathy, secreted, thyroid hormone, transport
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28247.13
Authors
Kolstoe, S.E.,Wood, S.P.,Pepys, M.B. (deposition date: 2009-08-17, release date: 2010-11-17, Last modification date: 2023-09-06)
Primary citationKolstoe, S.E.,Mangione, P.P.,Bellotti, V.,Taylor, G.W.,Tennent, G.A.,Deroo, S.,Morrison, A.J.,Cobb, A.J.,Coyne, A.,McCammon, M.G.,Warner, T.D.,Mitchell, J.,Gill, R.,Smith, M.D.,Ley, S.V.,Robinson, C.V.,Wood, S.P.,Pepys, M.B.
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Proc.Natl.Acad.Sci.USA, 107:20483-20488, 2010
Cited by
PubMed: 21059958
DOI: 10.1073/pnas.1008255107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

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