3ION

PDK1 in complex with Compound 8h

Summary for 3ION

• Entry DOI: 10.2210/pdb3ion/pdb
• Related: 3IOP
• Descriptor: 3-phosphoinositide-dependent protein kinase 1, 2-(5-{[(2S)-2-amino-3-phenylpropyl]oxy}pyridin-3-yl)-8,9-dimethoxybenzo[c][2,7]naphthyridin-4-amine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: pdk-1, inhibitor, alternative splicing, atp-binding, cytoplasm, kinase, membrane, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: O15530
• Total number of polymer chains: 1
• Total formula weight: 36150.48

Authors

Olland, A.M. (deposition date: 2009-08-14, release date: 2010-02-09, Last modification date: 2024-02-21)

• Primary citation: Nittoli, T.,Dushin, R.G.,Ingalls, C.,Cheung, K.,Floyd, M.B.,Fraser, H.,Olland, A.,Hu, Y.,Grosu, G.,Han, X.,Arndt, K.,Guo, B.,Wissner, A.; The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1).; Eur.J.Med.Chem., 45:1379-1386, 2010; PubMed: 20074837; DOI: 10.1016/j.ejmech.2009.12.036

Experimental method

X-RAY DIFFRACTION (2.4 Å)