3IMY

Structure of TR-beta bound to selective thyromimetic GC-1

Summary for 3IMY

Entry DOI	10.2210/pdb3imy/pdb
Descriptor	Thyroid hormone receptor beta, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid (3 entities in total)
Functional Keywords	alternative splicing, deafness, disease mutation, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, nuclear protein receptor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10828
Total number of polymer chains	1
Total formula weight	30182.54
Authors	Bleicher, L.,Polikarpov, L.,Aparicio, R. (deposition date: 2009-08-11, release date: 2009-09-08, Last modification date: 2023-09-06)
Primary citation	Bleicher, L.,Aparicio, R.,Nunes, F.M.,Martinez, L.,Gomes Dias, S.M.,Figueira, A.C.M.,Santos, M.A.M.,Venturelli, W.H.,da Silva, R.,Donate, P.M.,Neves, F.A.,Simeoni, L.A.,Baxter, J.D.,Webb, P.,Skaf, M.S.,Polikarpov, I. Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. BMC STRUCT.BIOL., 8:1-13, 2008 Cited by PubMed: 18237438 DOI: 10.1186/1472-6807-8-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation