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3IMS

Transthyretin in complex with 2,6-dibromo-4-(2,6-dichlorophenethyl)phenol

Summary for 3IMS
Entry DOI10.2210/pdb3ims/pdb
Related2QGB 2QGC 2QGD 2QGE 3ESN 3ESO 3IMR 3IMT 3IMU 3IMV 3IMW
DescriptorTransthyretin, 2,6-dibromo-4-[2-(2,6-dichlorophenyl)ethyl]phenol (3 entities in total)
Functional Keywordshormone, growth factor, amyloid, disease mutation, gamma-carboxyglutamic acid, glycoprotein, polymorphism, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28404.61
Authors
Connelly, S.,Wilson, I.A. (deposition date: 2009-08-11, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citationChoi, S.,Reixach, N.,Connelly, S.,Johnson, S.M.,Wilson, I.A.,Kelly, J.W.
A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
J.Am.Chem.Soc., 132:1359-1370, 2010
Cited by
PubMed: 20043671
DOI: 10.1021/ja908562q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

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