3IGP

Structure of inhibitor binding to Carbonic Anhydrase II

Summary for 3IGP

Entry DOI	10.2210/pdb3igp/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamide, ... (5 entities in total)
Functional Keywords	carbonic anhydrase inhibitors, isoquinolines, lyase, acetylation, cytoplasm, disease mutation, metal-binding, polymorphism, zinc
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	30083.30
Authors	Gitto, R.,Agnello, S.,Brynda, J.,Mader, P.,Supuran, C.T.,Chimirri, A. (deposition date: 2009-07-28, release date: 2010-03-09, Last modification date: 2023-11-01)
Primary citation	Gitto, R.,Agnello, S.,Ferro, S.,De Luca, L.,Vullo, D.,Brynda, J.,Mader, P.,Supuran, C.T.,Chimirri, A. Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as Potent Carbonic Anhydrase Inhibitors: Synthesis, Biological Evaluation, and Enzyme-Ligand X-ray Studies. J.Med.Chem., 2010 Cited by PubMed: 20170095 DOI: 10.1021/jm9014026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation