3IFP

X-ray structure of amyloid beta peptide:antibody (Abeta1-7:12B4) complex

Summary for 3IFP

• Entry DOI: 10.2210/pdb3ifp/pdb
• Related: 3IFL 3IFN 3IFO
• Descriptor: 12B4 FAB antibody heavy chain, 12B4 FAB antibody light chain, Amyloid beta A4 protein (3 entities in total)
• Functional Keywords: antibody, amyloid beta peptide, immune system
• Biological source: Mus musculus (mouse); More
• Cellular location: Membrane; Single-pass type I membrane protein: P05067
• Total number of polymer chains: 12
• Total formula weight: 198621.06

Authors

Weis, W.I.,Feinberg, H.,Basi, G.S.,Schenk, D. (deposition date: 2009-07-24, release date: 2009-11-17, Last modification date: 2013-09-25)

• Primary citation: Basi, G.S.,Feinberg, H.,Oshidari, F.,Anderson, J.,Barbour, R.,Baker, J.,Comery, T.A.,Diep, L.,Gill, D.,Johnson-Wood, K.,Goel, A.,Grantcharova, K.,Lee, M.,Li, J.,Partridge, A.,Griswold-Prenner, I.,Piot, N.,Walker, D.,Widom, A.,Pangalos, M.N.,Seubert, P.,Jacobsen, J.S.,Schenk, D.,Weis, W.I.; Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.; J.Biol.Chem., 285:3417-3427, 2010; PubMed: 19923222; DOI: 10.1074/jbc.M109.045187

Experimental method

X-RAY DIFFRACTION (2.95 Å)