3ICM

Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with isopentenyl pyrophosphate, Mg2+ and 1-(2-Hydroxy-2,2-bis-phosphono-ethyl)-3-phenyl-pyridinium

Summary for 3ICM

Entry DOI	10.2210/pdb3icm/pdb
Related	1YHK 1YHL 1YKM 3IBA 3ICK 3ICN 3ICZ 3ID0
Descriptor	Farnesyl pyrophosphate synthase, 1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium, SULFATE ION, ... (6 entities in total)
Functional Keywords	farnesyl diphosphate synthase, fpps, bisphosphonate, zoledronate, risedronate, minodronate, chagas disease, isoprene biosynthesis, transferase
Biological source	Trypanosoma cruzi
Total number of polymer chains	1
Total formula weight	42000.61
Authors	Amzel, L.M.,Huang, C.H.,Gabelli, S.B.,Oldfield, E. (deposition date: 2009-07-17, release date: 2010-02-09, Last modification date: 2024-02-21)
Primary citation	Huang, C.H.,Gabelli, S.B.,Oldfield, E.,Amzel, L.M. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins, 78:888-899, 2010 Cited by PubMed: 19876942 DOI: 10.1002/prot.22614 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation